Publication: PNAS.org | Publication Date: July 21, 2020 Authors: Lien D. Nguyen, Tom T. Fischer, Damien Abreu, Alfredo Arroyo, Fumihiko Urano, and Barbara E. Ehrlich Significance Wolfram syndrome is a rare multisystem disease characterized by diabetes insipidus, diabetes mellitus, optic nerve atrophy, and deafness (DIDMOAD). It is primarily caused by mutations in the Wolfram syndrome […]
Publication: Springer Link | Publication Date: March 26, 2020 Authors: K. Batjargal, T. Tajima, E. F. Jimbo & T. Yamagata Abstract Purpose Wolfram syndrome (WS) is a rare disorder caused by mutations in WFS1 that is characterized by diabetes mellitus, optic atrophy, sensorineural deafness, diabetes insipidus, and neurodegeneration. This disease is usually inherited as an […]
Publication: Nature.com | Publication Date: February 14, 2020 Authors: Damien Abreu, Rie Asada, John M. P. Revilla, Zeno Lavagnino, Kelly Kries, David W. Piston & Fumihiko Urano Abstract Wolfram Syndrome 1 (WFS1) protein is an endoplasmic reticulum (ER) factor whose deficiency results in juvenile-onset diabetes secondary to cellular dysfunction and apoptosis. The mechanisms guiding β-cell […]
Liraglutide restores chronic ER stress, autophagy impairments and apoptotic signalling in SH-SY5Y cells
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