Publication: journals.plos.org | Publication Date: January 6, 2009
Authors: Chihiro Kakiuchi, Shinsuke Ishigaki, Christine M. Oslowski, Sonya G. Fonseca, Tadafumi Kato, Fumihiko Urano
Abstract
Background
Valproate is a standard treatment for bipolar disorder and a first-line mood stabilizer. The molecular mechanisms underlying its actions in bipolar disorder are unclear. It has been suggested that the action of valproate is linked to changes in gene expression and induction of endoplasmic reticulum (ER) stress-response proteins.