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Wolfram Syndrome
Effects
©The Snow Foundation
Peripheral neuropathy
Autonomic nervous
system dysfunction
heat/cold intolerance
rapid heart rate
Peripheral Nervous System
Ulcers
(Wolfram syndrome type 2)
Bleeding
(Wolfram syndrome type 2)
Esophageal dysfunction
Bowel dysmotility
(chronic constipation
or diarrhea)
Gastrointestinal System
Reduced testosterone
(males)
Urinary hesitancy
Urinary incontinence
Bladder dysfunction
Hydronephrosis /
hydroureter
Urinary tract infections
(UTIs)
Urogenital System
Insulin shortage
(diabetes mellitus)
Pituitary gland
dysfunction
(diabetes insipidus)
Hormone
deficiencies/
growth delay
Endocrine System
Hearing loss
Balance & coordination
problems
Irregular breathing
Neurodegeneration
Loss of sense
of smell
Neuropsychiatric
symptoms
Loss of gag reflex
Muscle spasms
Seizures
Depression
Anxiety
Sleep disturbance
Central Nervous System
Vision loss
Cataracts
Ophthalmologic System
The Effects of Wolfram Syndrome
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