Mapping the WFS1 Interactome in Wolfram Syndrome: From Mechanisms to Therapeutic Leads
Principal Investigator Dr. Mariana Igoillo-Esteve, Co-Investigator Ane Olazagoitia-Garmendia, Brussels, Belgium
New potential WFS1 interactors were discovered by Dr. Igoillo-Esteve in 2025.
This work aims to validate the new interactome data obtained in 2025, uncover the molecular pathways in which they are involved, and characterize their roles in cellular function, ER stress, and survival.
Following this interactome identification, this project will prioritize and test compounds targeting the most relevant pathways identified.
This project aims to:
Uncover cellular mechanisms that result in Wolfram syndrome by identifying molecular functions of WFS1
Pave the way for innovative therapeutic strategies.
http://thesnowfoundation.org/wp-content/uploads/2019/06/snow-foundation_logo.svg00The Snow Foundationhttp://thesnowfoundation.org/wp-content/uploads/2019/06/snow-foundation_logo.svgThe Snow Foundation2026-02-19 19:48:462026-02-19 19:48:46Mapping the WFS1 Interactome in Wolfram Syndrome: From Mechanisms to Therapeutic Leads