Principal Investigators- Drs. Raniero Chimienti and Giulio Frontino, Milan, Italy
This work is done in collaboration with Telethon Foundation, Italy
This project is designed to test whether immune cells that have been genetically corrected can help improve the inflammatory symptoms of Wolfram syndrome in a mouse model.
By transplanting genetically corrected WS immune cells into mice with Wolfram syndrome, researchers will study whether inflammation is reduced and whether the progression of Wolfram syndrome symptoms can be slowed by addressing/reducing inflammation.
http://thesnowfoundation.org/wp-content/uploads/2019/06/snow-foundation_logo.svg00The Snow Foundationhttp://thesnowfoundation.org/wp-content/uploads/2019/06/snow-foundation_logo.svgThe Snow Foundation2026-02-19 19:34:142026-02-19 19:34:14WFS1 Gene Therapy to correct chronic inflammation due to Wolframin loss of function mutations