Patients with Wolfram syndrome face multiple challenges in addition to diabetes. That’s why I always feel that Wolfram is the most difficult form of diabetes. Mood swings, anxiety, and depression are commonly seen. Although the molecular mechanisms underlying these symptoms are not clear, we assume that these are related to the dysregulation of neurotransmitter secretion. […]
Here are two other questions I often get. Q: How can we use stem cells for the treatment of Wolfram syndrome and Type 1 diabetes. A: Stem cells can differentiate into specific cell types including insulin-producing cells, retinal cells, and brain cells. The most important function of stem cells, especially induced pluripotent stem cells (iPS cells), […]
I receive many questions related to Wolfram syndrome and other medical conditions. Here are some of them. Please feel free to contact me if you have any questions. Q: What is diabetes insipidus? A: Diabetes insipidus is one of the common symptoms in patients with Wolfram syndrome. It is defined as the passage of large […]
I was watching the video that our friend and patient, Alejandro, was doing an ice bucket challenge. This project originally started for ALS. So I was checking the ALS-related websites and found the following youtube video. As most of you know, ALS (amyotrophic lateral sclerosis) is a neurodegenerative disease, leading to the progressive degeneration of […]
Today I would like to begin by thanking everyone who has been reading my blogs. I checked the statistics function of my blogs yesterday and found something unexpected. Several thousand people read my blogs every week! Why? I don’t know, but I was so moved and surprised. I am so glad that many people are interested in […]
We have created many induced pluripotent stem cells (iPS cells) from skin cells of Wolfram syndrome patients. Because these cells can be differentiated into any types of cells, including brain cells, eye cells, and insulin-producing pancreatic cells, we can use these cells to replace damaged tissues in our patients in the future. In addition to […]
I think about this topic every day. I firmly believe that our future clinic for Wolfram syndrome and other ER stress disorders should provide “Personalized Medicine.” This 2 min-video explains about the personalized medicine very well. https://www.youtube.com/watch?v=QFzMP-UNwLs Why? As I mentioned before, each patient is different, and should be treated differently. The key is to […]
I think a lot about a new platform for endoplasmic reticulum disease and other rare diseases. The new clinic requires new expertise in addition to conventional neurology, ophthalmology, and endocrinology. I feel that regenerative therapy and modern medical genetics based on high-throughput sequencing are the key players. I found an interesting video describing regenerative medicine. […]
One of my goals is to practice “Personalized Medicine” in our clinic because each patient is different. The power of genetic medicine should be fully utilized. I believe that whole genome sequencing and exome sequencing are useful for making an accurate diagnosis. The information we get from patient’s DNA can be utilized to choose the […]
I talked about medicine and DNA too much in the past several days. So let’s take a break and talk about Dr. Permutt. As many of you know, I took over Dr. Alan Permutt’s research program on Wolfram syndrome two years ago. I believe that it was controversial that a young foreign physician would take […]
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