8th International Wolfram Symposium Presentation Randal Hand PhD – Director of Neuroscience Research, Prilenia Therapeutics 

8th International Wolfram Symposium Presentation Randal Hand PhD – Director of Neuroscience Research, Prilenia Therapeutics
 
Pridopidine: A selective and potent S1R agonist as a potential treatment for Wolfram Syndrome
 

Points noted:
•  Pridopidine is currently in clinical trials for neurodegenerative conditions (e.g. ALS (Ph II moving into Ph III); Huntington’s (Ph III).
•  Currently being explored in WS due to commonalities in cellular pathways.
•  Rescue with Pridopidine has been shown to reduce ER stress and improve mitochondrial respiration in WS models.
•  Nausea and dizziness have been reported side-effects (fairly typical side- effects).
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