β cell dedifferentiation, the underlying mechanism of diabetes in Wolfram syndrome

Publication: science.org | Publication Date: 2025

Authors: Kikuko Amo-Shiinoki et al.

Abstract

Insulin-dependent diabetes in patients with Wolfram syndrome (WS; OMIM 222300) has been linked to endoplasmic reticulum (ER) stress caused by WFS1 gene mutations. However, the pathological process of ER stress–associated β cell failure remains to be fully elucidated. Our results indicate loss of β cell lineage and subsequent dedifferentiation as the mechanisms underlying functional and mass deficits in WS.
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6th Annual Golf Shootout, Sept 8, 2025

Golf Shootout 2025

Join us for a great event on September 8, 2025 at Bogey Hills Country Club to support The Snow Foundation. The day will feature, 10 Par 3 holes with unique hole in on contests, 4 Par 4’s and 4 Par 5 Long Drive holes, a $100,000 Shootout for 10 Golfers.

Download the flyer for registration and sponsorship opportunities.

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10th International Congress of Clinicians and Researchers, June 13 & 14th 2025, Paris, France

June 13 & 14th 2025, Paris, France

The 10th International Congress of Clinicians and Researchers aims to evaluate current research efforts, present the results of the TreatWolfram clinical trial, and assess medical care.

Click here for event details.

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