β cell dedifferentiation, the underlying mechanism of diabetes in Wolfram syndrome

Publication: science.org | Publication Date: 2025

Authors: Kikuko Amo-Shiinoki et al.

Abstract

Insulin-dependent diabetes in patients with Wolfram syndrome (WS; OMIM 222300) has been linked to endoplasmic reticulum (ER) stress caused by WFS1 gene mutations. However, the pathological process of ER stress–associated β cell failure remains to be fully elucidated. Our results indicate loss of β cell lineage and subsequent dedifferentiation as the mechanisms underlying functional and mass deficits in WS.

Full article

Kikuko Amo-Shiinoki et al. ,β cell dedifferentiation, the underlying mechanism of diabetes in Wolfram syndrome.Sci. Transl. Med.17,eadp2332(2025).DOI:10.1126/scitranslmed.adp2332. Retrieved February 23, 2025, from https://doi.org/10.1126/scitranslmed.adp2332.

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