Research News

Wolfram Research Clinic Day 1: Biomarker???

Wolfram research clinic is ongoing and our patients are going through many tests. At this year’s clinic, we are collecting blood samples from not only patients but also their parents and siblings. Why? The reason is we plan to measure “BIOMARKER” levels in these samples. What is a biomarker? A biomarker is a molecule found […]

Wolfram Research Clinic – Day 0

By Dr. Fumihiko Urano Our annual Wolfram syndrome research clinic will start today, and I met with most of the patients and their families last night. I have been very impressed by them. In this clinic, we don’t provide any treatment. We just collect information and samples from patients, their parents and siblings. All of […]

Wolfram syndrome timeline

2008 – Studies show that WFS1 is one of top ten causative candidate genes for T2D. (ref 5). 2010 – Wolfram Syndrome International Registry and Research Clinic started. 2011 – Snow Fund contributes to Research Clinic beginning in year two and to Permutt lab research 2011. 2012 – Dr. Permutt dies June 6, 2012. 2012 […]

Wolfram Syndrome Links

Wolfram syndrome Links Of Interest Please click on the links listed below to visit other web sites that can help you find more information to obtain knowledge on Wolfram syndrome. Washington University School of Medicine – Wolfram Syndrome Blog Wolfram syndrome (OMIM) Wolfram syndrome Family support: Worldwide Society of Wolfram syndrome Families UK Wolfram Syndrome […]

Study to analyze brains of kids with rare disorder

October 26, 2012 Researchers at Washington University School of Medicine in St. Louis have received a five-year, $2.7 million grant to detect and analyze differences in the brains of children with a rare illness, Wolfram syndrome. The disorder, which is caused by mutations in a single gene, includes a severe form of diabetes, hearing and vision loss […]

2012 Wolfram Syndrome Research Update

Compiled By: Tamara Hershey, Ph.D., Bess Marshall, M.D., Fumi Urano, M.D., Ph.D. and the WU Wolfram Study Group members Overview This past year has been an exciting but also difficult one for our group and for the Wolfram community. While we have made great gains in our research efforts, we also lost our friend, colleague […]

Treatment target for diabetes, Wolfram syndrome

August 7, 2012 Inflammation and cell stress play important roles in the death of insulin-secreting cells and are major factors in diabetes. Cell stress also plays a role in Wolfram syndrome, a rare, genetic disorder that afflicts children with many symptoms, including juvenile-onset diabetes. The bright green spots are TXNIP molecules, potential treatment targets for […]

Wolfram Syndrome Researcher Makes Headlines

Tamara Hershey was recently featured on the Washington University School of Medicine website for her studies in how fluctuations in glucose levels can influence the brain .  As well as her work as a neuroscientist, she devotes much of her time studying Wolfram syndrome. “Endocrinologists usually are interested in Wolfram syndrome because it’s a genetic form […]

Snow White Fellowship

Wolfram Moms Join Forces to Create “Snow White Fellowship” In the fall of 2013, Stephanie Snow Gebel and Beth White decided to join forces and create “The Snow White Fellowship” at Washington University School of Medicine. The Jack & J.T. Snow Scientific Research Foundation and The Ellie White Foundation for Rare Genetic Disorders decided to join […]

Patient Based Therapeutics – New Drug Candidates

New Drug Candidates As I mentioned in my previous blogs, we have identified three FDA-approved drugs, one supplement, and new groups of drugs that can potentially delay the progression of Wolfram syndrome. We have been testing the efficacy of these drugs in cells from patients and two animal models of Wolfram syndrome. Preliminary data look […]