Entries by Fumihiko Urano

iPS cells and Personalized Medicine

We have created many induced pluripotent stem cells (iPS cells) from skin cells of Wolfram syndrome patients. Because these cells can be differentiated into any types of cells, including brain cells, eye cells, and insulin-producing pancreatic cells, we can use these cells to replace damaged tissues in our patients in the future. In addition to […]

A platform for providing the best treatment for patients with ER Disease: Personalized Medicine

I think about this topic every day. I firmly believe that our future clinic for Wolfram syndrome and other ER stress disorders should provide “Personalized Medicine.” This 2 min-video explains about the personalized medicine very well. Why? As I mentioned before, each patient is different, and should be treated differently. The key is to obtain […]

Regenerative Therapy and Modern Medical Genetics

I think a lot about a new platform for endoplasmic reticulum disease and other rare diseases. The new clinic requires new expertise in addition to conventional neurology, ophthalmology, and endocrinology. I feel that regenerative therapy and modern medical genetics based on high-throughput sequencing are the key players. I found an interesting video describing regenerative medicine. […]

The Last Advice from late Dr. Alan Permutt

I talked about medicine and DNA too much in the past several days. So let’s take a break and talk about Dr. Permutt. As many of you know, I took over Dr. Alan Permutt’s research program on Wolfram syndrome two years ago. I believe that it was controversial that a young foreign physician would take […]

Combating Wolfram Syndrome

We have the pleasure of sharing the posts from Dr. Urano’s blog “Combating Wolfram Syndrome”.  Below are his posts for the week of July 21-25. Friday, July 25, 2014 Endoplasmic Reticulum Disease Clinic 1 Thank you for your feedback for my blog. http://wolframsyndrome.blogspot.com/2014/07/a-platform-for-providing-immediate-care_24.html We need to consider multiple factors and logistics for establishing “Endoplasmic Reticulum Disease […]

Three Step Formula to Provide a Cure for Wolfram Syndrome

I presented my strategy for providing a cure for Wolfram syndrome at the clinic this weekend. I think there are three steps to achieve this. 1. Stop the progression2. Protect and Regrow remaining tissues3. Replace damaged tissues Our current focus is to “Stop the progression” of the disease. We are testing if FDA-approved drugs currently […]